CLA (Conjugated Linoleic Acid) What is it? CLA is actually a family of polyunsaturated fatty acids that are usually obtained in the diet by consuming the meat of grass-fed ruminants (beef), the eggs or meat of free-range chickens, white button...
CLA is actually a family of polyunsaturated fatty acids that are usually obtained in the diet by consuming the meat of grass-fed ruminants (beef), the eggs or meat of free-range chickens, white button mushrooms (Agaricus bisporus), or from safflower oil-based nutritional supplements.
Why would I take it?
To induce fat loss or to increase lean muscle tissue overall.
How does this work?
Though several mechanisms have been theorized, the exact mechanism remains unknown. The most likely mechanism that CLA has on fat metabolism and storage seems to be through being a weak modulator of PPAR-gamma (which controls fat storage) and through the upregulation of UCP-2, a thermogenic protein.
How much should I take?
Most clinical studies have investigated a 70% pure CLA with a dose range of 3.2-6.4 grams per day. This yields an actual 2.24-4.48 grams of CLA per day. With Glaxon Pharma’s CLA90, we have an 80% standardization of CLA from safflower oil. At 3 softgels per day (best taken with meals) this actually yields a nice, “middle-of-the-road” dose of 3 grams of CLA per day.
Top 5 Studies:
1 - Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study.